lethargy — the quality or state of being drowsy and dull, listless and unenergetic, or indifferent and lazy; apathetic or sluggish inactivity.
weakness — the state or quality of being weak; lack of strength, firmness, vigor, or the like; feebleness.
disease — a disordered or incorrectly functioning organ, part, structure, or system of the body resulting from the effect of genetic or developmental errors, infection, poisons, nutritional deficiency or imbalance, toxicity, or unfavorable environmental factors; illness; sickness; ailment.
enervation — A feeling of being drained of energy or vitality; fatigue.
helplessness — unable to help oneself; weak or dependent: a helpless invalid.
idleness — the quality, state, or condition of being lazy, inactive, or idle: His lack of interest in the larger world and his consummate idleness were the causes of their dreadful divorce.
impotence — the condition or quality of being impotent; weakness.
inability — lack of ability; lack of power, capacity, or means: his inability to make decisions.
inadequacy — Also, inadequateness [in-ad-i-kwit-nis] /ɪnˈæd ɪ kwɪt nɪs/ (Show IPA). the state or condition of being inadequate; insufficiency.
incompetence — the quality or condition of being incompetent; lack of ability.
inefficiency — the quality or condition of being inefficient; lack of efficiency.
ineptness — without skill or aptitude for a particular task or assignment; maladroit: He is inept at mechanical tasks. She is inept at dealing with people.
lack — something missing or needed: After he left, they really felt the lack.
powerlessness — unable to produce an effect: a disease against which modern medicine is virtually powerless.
fear — a river in SE North Carolina. 202 miles (325 km) long.
apathy — You can use apathy to talk about someone's state of mind if you are criticizing them because they do not seem to be interested in or enthusiastic about anything.