All run-of-the-mill antonyms

adjective run-of-the-mill

• landmark — a prominent or conspicuous object on land that serves as a guide, especially to ships at sea or to travelers on a road; a distinguishing landscape feature marking a site or location: The post office served as a landmark for locating the street to turn down.
• milestone — a stone functioning as a milepost.
• elite — A group of people considered to be the best in a particular society or category, esp. because of their power, talent, or wealth.
• different — not alike in character or quality; distinct in nature; dissimilar: The two brothers are very different, although they are identical twins.
• handpicked — Picked by hand; picked or selected with care.