noun molise a region of S central Italy, the second smallest of the regions: separated from Abruzzi e Molise in 1965. Capital: Campobasso. Pop: 321 047 (2003 est). Area: 4438 sq km (1731 sq miles) 0
noun molise region of SC Italy: 1,714 sq mi (4,439 sq km); pop. 331,000 0